In Manhattan, the British limousine driver Alfie is surrounded by beautiful women, having one night stands with all of them and without any sort of commitment. His best friends are his colleague Marlon and his girl-friend Lonette. Alfie has a brief affair with Lonette, and the consequences of his act forces Alfie to reflect over his lifestyle.
With the impending ice age almost upon them, a mismatched trio of prehistoric critters – Manny the woolly mammoth, Diego the saber-toothed tiger and Sid the giant sloth – find an orphaned infant and decide to return it to its human parents. Along the way, the unlikely allies become friends but, when enemies attack, their quest takes on far nobler aims.